Product Description for flt3-Ligand (flk2-Ligand)
Properties for flt3-Ligand (flk2-Ligand)
|Product Category||Proteins & Growth Factors|
|Molecular weight||16 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 98 % greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by reducing and non-reducing SDS-PAGE
|Background||FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation.|
|General Readings||1. Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy. J Immunother 2004 Jan-Feb;27(1):13-26
2. Impact of the tumor microenvironment on host infiltrating cells and the efficacy of flt3-ligand combination immunotherapy evaluated in a treatment model of mouse prostate cancer. Cancer Immunol Immunother 2003 Sep;52(9):535-45
3. Orthotopic treatment model of prostate cancer and metastasis in the immunocompetent mouse: efficacy of flt3 ligand immunotherapy. Int J Cancer 2003 Dec 10;107(5):773-80
4. Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model.
Int Immunopharmacol 2001 Nov;1(12):2081-9
5. Neutralization of IL-12 reverses rejection of mouse liver allografts from Flt3-ligand-treated donors and is associated with suppression of both cellular and humoral responses. Transplant Proc 2001 Feb-Mar;33(1-2):525
|Storage||Lyophilized FLT3-Ligand although stable at room temperature for 3 weeks, should be stored desiccated below -18°C.
Upon reconstitution FLT3 should be stored at 2-8°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Shelf life: one year from despatch.