discontinued

AR03025BT-N Geldanamycin

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1 mg / €340.00

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Geldanamycin

Product Description for Geldanamycin

Geldanamycin.
Presentation: Biotin

Properties for Geldanamycin

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms Hsp90 inhibitor
Presentation Biotin
Molecular weight 1150.4
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % 98 %
Background Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1, 2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3).
This inhibitor is a useful tool for affinity purification of HSP-90 and HSP-90 dependent client proteins (4).
General Readings
  1. Whitesell L., et al. (1994) Proc. Natl Acad. Sci. USA 91:8324.
  2. Neckers L. (2002) Trends Mol. Med. 8: S55.
  3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
  4. Clevenger R.C. et al. (2004) J. Org. Chem. 69: 4375.
Storage Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Protect from light!
Shelf life: One year from despatch.
Source Synthetic
Description
Description:
Formula: C55H87N7O17S
Molecular weight:
1150.4
Format
Purity:
>98% 98 %
State:
Purple solid, conjugated to biotin
Reconstitution:
Soluble in DMSO
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