AR03025FC-N Geldanamycin

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1 mg / €290.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Geldanamycin

Product Description for Geldanamycin

Geldanamycin.
Presentation: FITC

Properties for Geldanamycin

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms Hsp90 inhibitor
Presentation FITC
Molecular weight 1034.2
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % 98 % (TLC: 10 % Methanol.methylene chloride; Rf=0.31)
Background Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3).
This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors (4). May also be used for detection of cell surface Hsp90 (5). Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays (6,7)
General Readings
  1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324.
  2. Neckers L. (2002) Trends Mol. Med. 8: S55.
  3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
  4. Llauger-Bufi L., et al. (2003) Bioorg. Med. Chem. Lett. 13: 3975.
  5. Tsutsumi S., et al. (2007) Oncogene October 29 Epub
  6. Kim J., et al. (2006) J. Biomol. Screen 9: 375.
  7. Gooljarsingh L.T. et al.(2006) Proc. Natl. Acad. Sci. USA 103: 7625.
Storage Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Protect from light.
Shelf life: One year from despatch.
Source Synthetic
Description
Description:
Formula: C55H63N5O13S
Molecular weight:
1034.2
Format
Purity:
>98% 98 % (TLC: 10 % Methanol.methylene chloride; Rf=0.31)
State:
Purple solid - FITC
Reconstitution:
Soluble in DMSO (>10mg/ml)
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