Product Description for Geldanamycin
Properties for Geldanamycin
|Product Category||Proteins & Growth Factors|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 98 % 98 % (TLC: 10 % Methanol.methylene chloride; Rf=0.31)|
|Background||Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3).
This is specifically a novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for Hsp90 inhibitors (4). May also be used for detection of cell surface Hsp90 (5). Other geldanamycin fluorophores (BODPY) have been reported and used in FP HTS assays (6,7)
|Storage||Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Protect from light.
Shelf life: One year from despatch.