AR03025PU-L Geldanamycin

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5 mg / €440.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Product Description for Geldanamycin

Presentation: Purified

Properties for Geldanamycin

Product Category Proteins & Growth Factors
Quantity 5 mg
Synonyms Hsp90 inhibitor
Presentation Purified
Molecular weight 560.6
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 95 % > 95 %
Background Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1α (3).
It is also an inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. It inhibits the transforming activity of abl, erbB, fps, src, and yes (4).
Geldanamycin is capable of destabilizing several oncogene and proto-oncogene products; it is a potent inhibitor of the nuclear hormone receptor family (5). It protects against α-synuclein toxicity to dopaminergic neurons in Drosophila, and destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines (6).
Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells (6). It is ~10- fold more potent than herbimycin A.
General Readings
  1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324.
  2. Neckers L. (2002) Trends Mol. Med. 8: S55.
  3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
  4. Chavany C., et al. 1996) Amer. Society Biochem Mol Bio. 9: 4974-4977.
  5. Villa R., et al. (2003) Carcinogenesis. 24(5): 851-9.
  6. Yamaki H., Iguchi-Ariga S.M., and Ariga H. (1989) J Antibiot (Tokyo) 42(4): 604-10.
Storage Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Protect from light!
Shelf life: One year from despatch.
Formula: C29H40N2O9
Molecular weight:
>95% > 95 %
Yellow solid, produced by fermentation
Slightly soluble in methanol, chloroform or DMSO (10 mg/ml); insoluble in water.
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