NB610-81561 Geldanamycin

Search for all "Geldanamycin"

1 mg / €360.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Not tested in other species. Geldanamycin

NB610-81561

Product Description for Geldanamycin

Not tested in other species. Geldanamycin.
Presentation: FITC

Properties for Geldanamycin

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms Hsp90 inhibitor
Presentation FITC
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Add. information Synthetic Geldanamycin-FITC
Soluble in DMSO (>10mg/mL)
Purple solid
Application , Synthetic Geldanamycin-FITC Soluble in DMSO (>10mg/mL) Purple solid
Background Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1
General Readings 1. Whitesell L., et al. (1994) Proc. Natl. Acad. Sci. USA 91:8324.
2. Neckers L. (2002) Trends Mol. Med. 8:S55.
3. Mabjeesh N.J., et al. (2002) Cancer Res. 62: 2478.
4. Llauger-Bufi L., et al. (2003) Bioorg. Med. Chem. Lett. 13: 3975.
5. Tsutsumi S., et al. (2007) Oncogene October 29 Epub
6. Kim J., et al. (2006) J. Biomol. Screen 9:375.
7. Gooljarsingh L.T. et al.(2006) Proc. Natl. Acad. Sci.
USA 103: 7625.
Storage Store at -20C. Avoid freeze-thaw cycles.
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