AR51578PU-N HCV Envelope glycoprotein E2 (482-671, His-tag)

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0.5 mg / €730.00
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Quick Overview

HCV Envelope glycoprotein E2

Product Description for HCV Envelope glycoprotein E2

HCV Envelope glycoprotein E2.
Presentation: Purified

Properties for HCV Envelope glycoprotein E2

Product Category Proteins & Growth Factors
Quantity 0.5 mg
Synonyms Hepatitis C Virus NS1, gp68, gp70
Presentation Purified
Molecular weight 25.4 kDa
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 80 % by SDS - PAGE
Background E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells.
Concentration 0.25 mg/ml (determined by Bradford assay)
General Readings Taylor D.R., et al. (2001) J. Virol. 75:1265-1273Kalliampakou K.I., et al. (2015) J. Gen. Virol. 86:1015-1025
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description
Description:
Recombinant HCV(Hepatitis C Virus) E2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
AA Sequence:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ
Molecular weight:
(226aa)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Purity:
>80% by SDS - PAGE
State:
Liquid purified protein
Purified
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