AR51559PU-N HCV NS5A (2210-2306, His-tag)

Search for all "HCV NS5A"

0.1 mg / €730.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

HCV NS5A

Product Description for HCV NS5A

HCV NS5A.
Presentation: Purified

Properties for HCV NS5A

Product Category Proteins & Growth Factors
Quantity 0.1 mg
Synonyms Hepatitis C Virus Non-structural protein NS5A
Presentation Purified
Molecular weight 13.4 kDa
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 90 % by SDS - PAGE
Background NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. This protein down-regulates viral IRES translation initiation and mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. NS5a seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication.
Concentration 0.25 mg/ml (determined by Bradford assay)
General Readings Taylor D.R., et al. (2001) J. Virol. 75:1265-1273Kalliampakou K.I., et al. (2015) J. Gen. Virol. 86:1015-1025
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description
Description:
Recombinant HCV(Hepatitis C Virus) NS5b protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MSLKATCTAN HDSPDAELIE ANLLWRQEMG GNITRVESENKVVILDSFDP LVAEEDEREV SVPAEILRKS RRFARALPVW ARPDYNPPLV ETWKKPDY
Molecular weight:
(118aa) confirmed by MALDI-TOF
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 1mM DTT
Purity:
>90% by SDS - PAGE
State:
Liquid purified protein
Purified
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