Product Description for Hepatitis B Core /HBcAg
Hepatitis B Core /HBcAg.
Presentation: Purified
Presentation: Purified
Properties for Hepatitis B Core /HBcAg
| Product Category | Proteins & Growth Factors |
|---|---|
| Quantity | 1 mg |
| Presentation | Purified |
| Source | E. coli |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Purity | >90% pure as determined by 10% PAGE (coomassie staining). Purification Method: Protein Precipitation. |
|---|---|
| Application | Antigen in ELISA and Western blots, excellent antigen for detection of HBV with minimal specificity problems. |
| Background | Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA(pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA. |
| Concentration | 1.0 mg/ml |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
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