Product Description for Hepatitis B E Antigen / HBeAg
Properties for Hepatitis B E Antigen / HBeAg
|Product Category||Proteins & Growth Factors|
|Synonyms||HBV External core antigen, HBV Precore protein|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 95 % pure as determined by 10% PAGE (coomassie staining).|
|Background||Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.|
|Storage||The protein can be shipped at 2-8°C.
Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.