PA1300XC Hepatitis B E Antigen / HBeAg

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Hepatitis B E Antigen / HBeAg


Product Description for Hepatitis B E Antigen / HBeAg

Hepatitis B E Antigen / HBeAg.
Presentation: Purified

Properties for Hepatitis B E Antigen / HBeAg

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms HBV External core antigen, HBV Precore protein
Presentation Purified
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 95 % pure as determined by 10% PAGE (coomassie staining).
Application ELISA.
Western blots.
Background Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. (HIV, a completely unrelated virus, also uses reverse transcription, but it is a retrovirus.) HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes (RC-DNA) are repaired to form a covalently closed circular DNA (cccDNA), which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA (pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA.
Concentration 1.0 mg/ml
General Readings
  1. Kanwal F, Gralnek IM, Martin P, Dulai GS, Farid M, Spiegel BM. Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis. Ann Intern Med. 2005 May 17;142(10):821-31. PubMed PMID: 15897532.
  2. Summaries for patients. Antiviral regimens for chronic hepatitis B virus infection. Ann Intern Med. 2005 May 17;142(10):I39. PubMed PMID: 15897528.
  3. Silva PA, Fiaccadori FS, Borges AM, Silva SA, Daher RR, Martins RM, et al. Seroprevalence of hepatitis B virus infection and seroconvertion to anti-HBsAg in laboratory staff in Goiânia, Goiás. Rev Soc Bras Med Trop. 2005 Mar-Apr;38(2):153-6. Epub 2005 Mar 30. PubMed PMID: 15821790.
  4. Tangkijvanich P, Mahachai V, Komolmit P, Fongsarun J, Theamboonlers A, Poovorawan Y. Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand. World J Gastroenterol. 2005 Apr 21;11(15):2238-43. PubMed PMID: 15818732.
  5. Paul S, Tabassum S, Islam MN. Interferon-gamma (IFN-gamma) response to different hepatitis B virus antigens in hepatitis B virus infection. Bangladesh Med Res Counc Bull. 2004 Aug;30(2):71-7. PubMed PMID: 15813485.
  6. Aras C, Ozdamar A, Ergin S, Ozturk R, Midilli K, Karacorlu M, et al. Failure to detect hepatitis B virus in vitreous by polymerase chain reaction. Ophthalmologica. 2005 Mar-Apr;219(2):93-6. PubMed PMID: 15802933.
Storage The protein can be shipped at 2-8°C.
Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
The E. Coli derived recombinant protein contains the HBV HBe adw immunodominant region is fused to GST.Purified by proprietary chromatographic technique.
Biological activity:
Immunoreactive with sera HBV-infected individuals.
Molecular weight:
43.7 kDa
Buffer System:
25mM Tris-HCl pH 8.0, 1.5 M Urea and 50% Glycerol
>95% pure as determined by 10% PAGE (coomassie staining).
Liquid purified protein
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