discontinued

AR10620PU-L HIV-2 gp32 env

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1 mg / €1,210.00

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HIV-2 gp32 env

AR10620PU-L

Product Description for HIV-2 gp32 env

HIV-2 gp32 env.
Presentation: Purified

Properties for HIV-2 gp32 env

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 95.0% as determined by HPLC analysis and SDS-PAGE
Application HIV-2 gp32 antigen is suitable for ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.
Background

HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids.
Immunodeficiency develops more slowly with HIV-2.
HIV-2 is less infectious in the early stages of the virus than with HIV-1.
The infectiousness of HIV-2 increases as the virus progresses.
Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anCHO (Chinese Hamster Ovary)red proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion.
HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C), does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, and is not affected by target membrane glycosphingolipid composition.

Storage

Store undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.

Description
Description:
HIV-2 gp32 recombinant- contains the full-length sequence of HIV-2 envelope immunodominant regions gp32. The protein is fused with beta-Galactosidase (114 kDa) at N-terminus.
Specificity: Immunoreactive with all sera of HIV-2 infected individuals.
Format
Buffer System:
0.01M Na2CO3, 0.01M Na3EDTA, 0.014 M beta-Mercaptoethanol, 0.05% Tween-20
Purity:
> 95.0% as determined by HPLC analysis and SDS-PAGE
State:
Liquid sterile filtered colorless clear solution
Purified
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