AR03026PU-N Hsp90 inhibitor (17-DMAG)

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1 mg / €200.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Hsp90 inhibitor (17-DMAG)

Product Description for Hsp90 inhibitor (17-DMAG)

Hsp90 inhibitor (17-DMAG).
Presentation: Purified

Properties for Hsp90 inhibitor (17-DMAG)

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Molecular weight 616.8
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % pure (TLC: 10% Methanol/methylene chloride; Rf=0.49)
Background 17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3).
This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.
General Readings
  1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077.
  2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381.
  3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source Synthetic
Purple Solid. 
Formula: C32H48N4O8
>98% pure (TLC: 10% Methanol/methylene chloride; Rf=0.49)
Purple solid
Soluble in DMSO (>30 mg/ml and ethanol (10 mg/ml)
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