AR03024PU-N HSP90 Inhibitor

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1 mg / €200.00
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HSP90 Inhibitor

Product Description for HSP90 Inhibitor

HSP90 Inhibitor.
Presentation: Purified

Properties for HSP90 Inhibitor

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms 17-AAG
Presentation Purified
Molecular weight 558.7
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % pure (TLC: 5% Methanol/Methylene Chloride, Rf=0.26).
Background Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17- AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5).
General Readings
  1. Neckers L. (2002) Trends Mol Med. 84: S55-61.
  2. Kamal A., et al.(2003) Nature 425: 407.
  3. Solit D.B., et al.(2003) Cancer Res. 63: 2139.
  4. Vasilevskaya I.A., et al. (2003) Mol.Pharmacol. 2003 65: 235.
  5. Jia W., et al.(2003) Blood 102: 1824.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source Synthetic.
Red to dark red powder.
CAS No: 75747-14-7
Formula: C31H43N3O8
>98% pure (TLC: 5% Methanol/Methylene Chloride, Rf=0.26).
Purple solid
Soluble in DMSO (>50 mg/ml) or Methanol (5 mg/ml).
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