AR03029PU-N Hsp90 inhibitor (Radicicol)

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1 mg / €210.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Hsp90 inhibitor

Product Description for Hsp90 inhibitor

Hsp90 inhibitor.
Presentation: Purified

Properties for Hsp90 inhibitor

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Molecular weight 364.8
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 97 % 97% by TLC
Background Radicicol inhibits src (IC50=0.27μM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.
General Readings
  1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.
  2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.
  3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221.
  4. Soga S., et al. (1998) J.Biol.Chem. 273:822.
  5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221.
  6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.
Storage Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Avoid repeated freezing and thawing.
Protect from light!
Shelf life: One year from despatch.
Formula: C18H17CIO6
Molecular weight:
>97% 97% by TLC
White to light yellow powder, produced by fermentation
Soluble in DMSO
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