discontinued

AR10668PU-L HTLV1 envelope

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1 mg / €570.00

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HTLV1 envelope

AR10668PU-L

Product Description for HTLV1 envelope

HTLV1 envelope.
Presentation: Purified

Properties for HTLV1 envelope

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity >95.0% pure as determined by HPLC-C4, and 10.0% PAGE. 
Purification Method: Organic extraction > Ceramic Hydroxyapatite > S-300.
Application Use as an antigen in ELISA and Western Blots. Excellent reagent forcorrect detection of HTLV infections, with minimal specificity problems.
Background Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
Concentration 1.0 mg/ml
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Description
Description:
The protein contains the C- terminus of gp46 and most of p21E of HTLV-I. This non-fusion, E.coli derived protein, starts from HIV-1 env. amino acid 165, and is ending in amino acid 440.
Specificity: Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
Format
Buffer System:
10 mM NaPO4 pH 6.0, containing 0.1% SDS, and 1 mM DTT
Purity:
>95.0% pure as determined by HPLC-C4, and 10.0% PAGE. 
Purification Method: Organic extraction > Ceramic Hydroxyapatite > S-300.
State:
Purified
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