discontinued

AR10668PU-N HTLV1 envelope

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0.5 mg / €390.00

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HTLV1 envelope

AR10668PU-N

Product Description for HTLV1 envelope

HTLV1 envelope.
Presentation: Purified

Properties for HTLV1 envelope

Product Category Proteins & Growth Factors
Quantity 0.5 mg
Presentation Purified
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity >95.0% pure as determined by HPLC-C4, and 10.0% PAGE. 
Purification Method: Organic extraction > Ceramic Hydroxyapatite > S-300.
Application Use as an antigen in ELISA and Western Blots. Excellent reagent forcorrect detection of HTLV infections, with minimal specificity problems.
Background Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
Concentration 1.0 mg/ml
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Description
Description:
The protein contains the C- terminus of gp46 and most of p21E of HTLV-I. This non-fusion, E.coli derived protein, starts from HIV-1 env. amino acid 165, and is ending in amino acid 440.
Specificity: Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
Format
Buffer System:
10 mM NaPO4 pH 6.0, containing 0.1% SDS, and 1 mM DTT
Purity:
>95.0% pure as determined by HPLC-C4, and 10.0% PAGE. 
Purification Method: Organic extraction > Ceramic Hydroxyapatite > S-300.
State:
Purified
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