discontinued

AR10664PU-L HTLV1 Mosaic

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1 mg / €1,210.00

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HTLV1 Mosaic

AR10664PU-L

Product Description for HTLV1 Mosaic

HTLV1 Mosaic.
Presentation: Purified

Properties for HTLV1 Mosaic

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity >95.0% pure as determined by 10.0% PAGE (coomassie staining) and RP-HPLC.
Purification Method: HTLV-1 Mosaic was purified by proprietary chromatographic technique.
Application HTLV-1 Mosaic can be used as an antigen in ELISA and Western Blots.
Excellent reagent for correct detection of HTLV infections, with minimal specificity problems.
Background

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).

Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Description
Description:
The E.coli derived recombinant mosiac protein contains the gp21 and gp46 immunodominant regions, 374-400 amino acids and 190-207 amino acids.
The protein is fused with GST at N-terminus.
Specificity: Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
Format
Buffer System:
60mM NaCl, 50mM Tris-HCl pH 8.0, 0.25% Sarkosil, 50% Glycerol and 10mM Glutathione
Purity:
>95.0% pure as determined by 10.0% PAGE (coomassie staining) and RP-HPLC.
Purification Method: HTLV-1 Mosaic was purified by proprietary chromatographic technique.
State:
Purified
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