discontinued

AR10664PU-S HTLV1 Mosaic

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0.1 mg / €280.00

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HTLV1 Mosaic

AR10664PU-S

Product Description for HTLV1 Mosaic

HTLV1 Mosaic.
Presentation: Purified

Properties for HTLV1 Mosaic

Product Category Proteins & Growth Factors
Quantity 0.1 mg
Presentation Purified
Source E. coli
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity >95.0% pure as determined by 10.0% PAGE (coomassie staining) and RP-HPLC.
Purification Method: HTLV-1 Mosaic was purified by proprietary chromatographic technique.
Application HTLV-1 Mosaic can be used as an antigen in ELISA and Western Blots.
Excellent reagent for correct detection of HTLV infections, with minimal specificity problems.
Background

Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).

Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Description
Description:
The E.coli derived recombinant mosiac protein contains the gp21 and gp46 immunodominant regions, 374-400 amino acids and 190-207 amino acids.
The protein is fused with GST at N-terminus.
Specificity: Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
Format
Buffer System:
60mM NaCl, 50mM Tris-HCl pH 8.0, 0.25% Sarkosil, 50% Glycerol and 10mM Glutathione
Purity:
>95.0% pure as determined by 10.0% PAGE (coomassie staining) and RP-HPLC.
Purification Method: HTLV-1 Mosaic was purified by proprietary chromatographic technique.
State:
Purified
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