SA6060X HTRA2 / PRSS25 (134-458, His-tag)

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0.5 mg / €540.00
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HTRA2 / PRSS25

SA6060X

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  • SA6060X
  • SA6060X

Product Description for HTRA2 / PRSS25

HTRA2 / PRSS25.
Presentation: Purified

Properties for HTRA2 / PRSS25

Product Category Proteins & Growth Factors
Target Category
Quantity 0.5 mg
Synonyms High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2
Presentation Purified
Molecular weight 36 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O43464
Purity > 95 % by SDS PAGE
Background HtrA2/Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death.
Concentration 0.5 mg/ml
General Readings Savopoulos JW., et al., (2000) Protein Expr. Purif. 19, 227-34.
Gray CW, et al., (2000) Eur. J. Biochem. 267, 5699-710.
Martins LM, et al., (2002) J. Biol. Chem. 277, 439-44.
Van Loo G, et al., (2002) Cell Death Differ. 9, 20-60.
Seong YM, et al., (2004) Protein Expr. Purif. 33, 200-8.
Storage Store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Mature form of HtrA2/Omi(residues 134-458), fused to His-tag, was overexpressed in E.coli, and purified by conventional column chromatography techniques.
AA Sequence:
MAVPSPPPAS PPSQYNFIAD VVEKTAPAVV YIEILDRHPF LGREVPISNG SGFVVAADGL IVTNAHVVAD RRRVRVRLLS GDTYEAVVTA VDPVADIATL RIQTKEPLPT LPLGRSADVR QGEFVVAMGS PFALQNTITS GIVSSAQRPA RDLGLPQTNV EYIQTDAAID FGNAGGPLVN LDGEVIGVNT MKVTAGISFA IPSDRLREFL HRGEKKNSSS GISGSQRRYI GVMMLTLSPS ILAELQLREP SFPDVQHGVL IHKVILGSPA HRAGLRPGDV ILAIGEQMVQ NAEDVYEAVR TQSQLAVQIR RGRETLTLYV TPEVTEGSHH HHHH
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0), 50 mM NaCl, 1 mM DTT, 20% Glycerol
Purity:
>95% by SDS PAGE
State:
Liquid purified protein
Purified
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