AR10452PU-S Interferon Tau

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Interferon Tau


Product Description for Interferon Tau

Interferon Tau.
Presentation: Purified

Properties for Interferon Tau

Product Category Proteins & Growth Factors
Quantity 0.1 U
Presentation Purified
Molecular weight 20 kDa
Source E. coli
Species (Protein) Bovine
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Swiss Prot Num:
Purity > 95% pure by SDS PAGE
Background IFN-tau is also known as TP-1 (trophoblast protein-1) is a new class of type I IFN that is secreted by the trophoblast and is the signal for maternal recognition of pregnancy in sheep. IFN- tau has potent immunosuppressive and antiviral activities similar to other type I IFN but is less cytotoxic than IFN-alpha and IFN-beta. The current investigation concerns the effect of recombinant ovine IFN- tau (rOIFN- tau) on the modulation of MHC class I and II expression on cloned mouse cerebrovascular endothelial (CVE) cells.
IFN-tau induced tyrosine phosphorylation of Stat1 and upregulated the expression of MHC class I on CVE. One proposed action by which type I IFN reduces the relapse rate in MS is via interference with IFN-?-induced MHC class II expression. IFN- tau was shown to downregulate IFN-?-induced MHC class II expression on CVE and, hence, may be of potential therapeutic value in downregulating inflammation in the central nervous system (CNS). IFN- tau did not upregulate the expression of MHC class II on CVE. IFN- tau also inhibited the replication of Theiler's virus in CVE. 

Store (in aliquots) at -20°C to -80°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Purified recombinant Bovine IFN-Tau protein.
Biological activity:
In this antiviral assay for interferon about 1 unit/ml of Interferon is the quantity necessary to produce a cytopathic effect of 50%
Buffer System:
0.1% BSA
> 95% pure by SDS PAGE
Liquid purified protein
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