discontinued

AR08001PU-S Interleukin-12 p80

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Interleukin-12

AR08001PU-S

Product Description for Interleukin-12

Interleukin-12.

Properties for Interleukin-12

Product Category Proteins & Growth Factors
Target Category
Quantity 2 µg
Synonyms CLMF p35, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL-12 subunit p35, IL-12A, NK cell stimulatory factor chain 1, NKSF1
Molecular weight 80 kDa
Source High-5 Insect cells
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P29460
Purity > 95 % pure by SDS-PAGE gel and HPLC analyses
Background IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source (BTI-Tn-5B1-4)
Description
Description:
Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.
AA Sequence:
p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
Format
Buffer System:
10mM Sodium Acetate, pH 5.6 with 90mM Sodium Chloride, 2% Sucrose and 4.0% Mannitol
Endotoxin level:
< 0.1 ng per µg (1EU/µg).
Purity:
>95% pure by SDS-PAGE gel and HPLC analyses
State:
Lyophilized (0.2µ Sterile filtered) purified protein
Reconstitution:
Restore in Water to a concentration of 0.1 mg/ml.
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