PA1096XC Interleukin-19 (IL-19)

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Interleukin-19 (IL-19)

Product Description for Interleukin-19 (IL-19)

Interleukin-19 (IL-19).
Presentation: Purified

Properties for Interleukin-19 (IL-19)

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms IL19
Presentation Purified
Molecular weight 18 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % Purified by proprietary chromatographic techniques, sterile Filtered, purity is greater than 99.0 % as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Background IL19 is a cytokine that belongs to the IL10 cytokine subfamily. IL-19 is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Concentration 1 mg/ml (prior to lyophil.)
General Readings
  1. Okayama N, Suehiro Y, Hamanaka Y, Nakamura J, Hinoda Y. Association of interleukin-19 gene polymorphisms with age. J Gerontol A Biol Sci Med Sci. 2007 May;62(5):507-11. PubMed PMID: 17522354.
  2. Zdanov A. Structural studies of the interleukin-19 subfamily of cytokines. Vitam Horm. 2006;74:61-76. PubMed PMID: 17027511.
  3. Hsing CH, Hsieh MY, Chen WY, Cheung So E, Cheng BC, Chang MS. Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass. Ann Thorac Surg. 2006 Jun;81(6):2196-201. PubMed PMID: 16731153.
  4. Chen PJ, Wei CC, Wang C, Chen FW, Hsu YH, Chang MS. Promoter analysis of interleukin 19. Biochem Biophys Res Commun. 2006 Jun 9;344(3):713-20. Epub 2006 Apr 7. PubMed PMID: 16631120.
  5. Otkjaer K, Kragballe K, Funding AT, Clausen JT, Noerby PL, Steiniche T, et al. The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis. Br J Dermatol. 2005 Nov;153(5):911-8. PubMed PMID: 16225599.
  6. Li HH, Lin YC, Chen PJ, Hsiao CH, Lee JY, Chen WC, et al. Interleukin-19 upregulates keratinocyte growth factor and is associated with psoriasis. Br J Dermatol. 2005 Sep;153(3):591-5. PubMed PMID: 16120148.
Storage Lyophilized product is stable at room temperature for one month, should be stored desiccated below -20 °C. Upon reconstitution it should be stored at 2 – 8 °C up to one week and for future use below -20 °C. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA). Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source E.coli
Interleukin-19 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids.
AA Sequence:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Arg-Arg-Cys.
Biological activity:
The activity is determined by it's ability to activate STAT following receptor-ligand interaction.
Molecular weight:
17913 Dalton.
Buffer System:
10 mM sodium citrate pH 5.
>98% Purified by proprietary chromatographic techniques, sterile Filtered, purity is greater than 99.0 % as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
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