PA1099 Interleukin-22 (IL-22)

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Interleukin-22 (IL-22)

Product Description for Interleukin-22 (IL-22)

Interleukin-22 (IL-22).
Presentation: Purified

Properties for Interleukin-22 (IL-22)

Product Category Proteins & Growth Factors
Quantity 2 µg
Synonyms IL22
Presentation Purified
Molecular weight 34 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 97 % Proprietary chromatographic techniques, sterile filtered,
> 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Background IL-22 is a member of the IL-10 family of regulatory cytokines. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.
General Readings
  1. Weber GF, Schlautkötter S, Kaiser-Moore S, Altmayr F, Holzmann B, Weighardt H. Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis. Infect Immun. 2007 Apr;75(4):1690-7. Epub 2007 Jan 29. PubMed PMID: 17261606. (Free PMC Article available, 4 images available)
  2. Zheng Y, Danilenko DM, Valdez P, Kasman I, Eastham-Anderson J, Wu J, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2007 Feb 8;445(7128):648-51. Epub 2006 Dec 24. PubMed PMID: 17187052.
  3. Wolk K, Sabat R. Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev. 2006 Oct;17(5):367-80. Epub 2006 Oct 9. PubMed PMID: 17030002.
  4. Interleukin-22 and its crystal structure. Vitam Horm 2006;74:77-103
  5. Chang H, Hanawa H, Liu H, Yoshida T, Hayashi M, Watanabe R, et al. Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. J Immunol. 2006 Sep 15;177(6):3635-43. PubMed PMID: 16951323.
  6. Pan H, Hong F, Radaeva S, Gao B. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol. 2004 Feb;1(1):43-9. PubMed PMID: 16212920.
Storage Lyophilized product is stable at room temperature for one month, should be stored desiccated below -20 °C. Upon reconstitution IL22 should be stored at 2 - 8 °C up to one week and at -20 °C for longer. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Shelf life: one year from despatch.
Source E.coli
Interleukin-22 Human Recombinant produced in E.Coli is a single, non-glycosylated homodimeric polypeptide chain containing 2 x 146 amino acids.
AA Sequence:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Ile-Ser.
Biological activity:
The Biological Acitivity was determined by the ability to activiate STAT following receptor ligand interaction.
Molecular weight:
33,607 Dalton.
Buffer System:
Each mg contains 1.6 mg mannitol and 1.2 mg HSA.
>97% Proprietary chromatographic techniques, sterile filtered,
> 97.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Sterile 18MO-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
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