discontinued

AR20010PU-S Interleukin-23 / IL23

Search for all "Interleukin-23 / IL23"

Quick Overview

Interleukin-23 / IL23

AR20010PU-S

Product Description for Interleukin-23 / IL23

Interleukin-23 / IL23.

Properties for Interleukin-23 / IL23

Product Category Proteins & Growth Factors
Target Category
Quantity 2 µg
Synonyms IL-23 subunit alpha, IL-23p19, IL-23p40, Interleukin-23 subunit p19, SGRF
Molecular weight 53.3 kDa
Source Insect cells
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9NPF7
Purity > 95 % pure by SDS-PAGE gel and HPLC analyses.
Add. information *Manufactured using BTI-Tn-5B1-4 cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Application Recombinant IL-23 is a 53.5 kDa heterodimeric protein consisting of two subunits, p19 (170 amino acids) and p40 (306 amino acids).
Background IL-23 is a proinflammatory heterodimeric protein composed of two subunits, a unique p19 subunit and a p40 subunit, which is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ2. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-gamma in NK cells, induces IL-17 production, and drives Th17 mediated responses.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source (BTI-Tn-5B1-4)*
Description
AA Sequence:

p19 Subunit
:

RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP

p40Subunit:
IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
Biological activity:
Measured by its ability to induce IL-17 secretion by mouse splenocytes.
Molecular weight:
(170aa + 306 aa)
Format
Buffer System:
1x PBS, pH 7.2
Endotoxin level:
< 0.1 ng per μg (1EU/μg).
Purity:
>95% pure by SDS-PAGE gel and HPLC analyses.
State:
Lyophilized (0.2µ sterile filtered) purified protein.
Reconstitution:
Restore in sterile water to a concentration of 0.5-1.0 mg/ml.
Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
  • LinkedIn