PA1084XC Interleukin-9 (IL-9)

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Interleukin-9 (IL-9)

Product Description for Interleukin-9 (IL-9)

Interleukin-9 (IL-9).
Presentation: Purified

Properties for Interleukin-9 (IL-9)

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Molecular weight 14 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Background Factor that is thought to be a regulator of hematopoiesis. It has been shown to enhance the growth of human mast cells and megakaryoblastic leukemic cells as well as murine helper t-cell clones. IL-9 is a glycoprotein with a molecular weight of 32-39 that is derived from T-cells, and maps to human chromosome 5.
Concentration 1 mg/ml
General Readings
  1. Qiu L, Lai R, Lin Q, Lau E, Thomazy DM, Calame D, et al. Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. Blood. 2006 Oct 1;108(7):2407-15. Epub 2006 Jun 8. PubMed PMID: 16763206. (Free PMC Article available, 7 images available)
  2. McNamara PS, Smyth RL. Interleukin-9 as a possible therapeutic target in both asthma and chronic obstructive airways disease. Drug News Perspect. 2005 Dec;18(10):615-21. PubMed PMID: 16491163.
  3. Devos S, Cormont F, Vrtala S, Hooghe-Peters E, Pirson F, Snick J. Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. Clin Exp Allergy. 2006 Feb;36(2):174-82. PubMed PMID: 16433854.
  4. Expression of interleukin-9 in nasal natural kill er/T-cell lymphoma cell lines and patients. Clin Cancer Res 2005 Dec 1;11(23):8250-7
  5. Poulin LF, Habran C, Stordeur P, Goldman M, McKenzie A, Van Snick J, et al. Interleukin-9 stimulates the production of interleukin-5 in CD4+ T cells. Eur Cytokine Netw. 2005 Sep;16(3):233-9. PubMed PMID: 16266865.
  6. Yang L, Aozasa K, Oshimi K, Takada K. Epstein-Barr virus (EBV)-encoded RNA promotes growth of EBV-infected T cells through interleukin-9 induction. Cancer Res. 2004 Aug 1;64(15):5332-7. PubMed PMID: 15289339.
Storage Lyophilized Interleukin-9 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL9 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Source E. coli
Interleukin-9 Human Recombinant produced in E.Coli is a single, non-glycosylated single polypeptide chain containing 127amino acids. The IL-9 is purified by proprietary chromatographic techniques.
AA Sequence:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Gln-Gly-Cys-Pro.
Biological activity:
The ED50 as determined by the dose-dependant stimulation of human MO7e cells is < 0.2 ng/ml, corresponding to a Specific Activity of 5 x 106 IU/mg.
Molecular weight:
14004 Dalton.
Buffer System:
Lyophilized from a concentrated solution in water containing no additives.
>98% Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Sterile Filtered White lyophilized (freeze-dried) powder.
It is recommended to reconstitute the lyophilized Interleukin-9 in sterile 18MĎ?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
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