discontinued

PA1085XC Interleukin-9 (IL-9)

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1 mg / €4,410.00

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Interleukin-9 (IL-9)

Product Description for Interleukin-9 (IL-9)

Interleukin-9 (IL-9).
Presentation: Purified

Properties for Interleukin-9 (IL-9)

Product Category Proteins & Growth Factors
Quantity 1 mg
Presentation Purified
Molecular weight 14 kDa
Source E. coli
Species (Protein) Mouse
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % Purified by proprietary chromatographic techniques, sterile filtered, purity > 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Add. information Protein quantitation was carried out by two independent methods:
1. UV spectroscopy at 280 nm using the absorbency value of 0.6 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
2. Analysis by RP-HPLC, using a standard solution of IL-9 as a Reference Standard.
Background Factor that is thought to be a regulator of hematopoiesis. It has been shown to enhance the growth of human mast cells and megakaryoblastic leukemic cells as well as murine helper t-cell clones. IL-9 is a glycoprotein with a molecular weight of 32-39 that is derived from T-cells, and maps to human chromosome 5.
Concentration 1 mg/ml (lyophil.)
General Readings
  1. Endo Y, Isono K, Kondo M, Tamaoki J, Nagai A. Interleukin-9 and Interleukin-13 augment UTP-induced Cl ion transport via hCLCA1 expression in a human bronchial epithelial cell line. Clin Exp Allergy. 2007 Feb;37(2):219-24. PubMed PMID: 17250694.
  2. Qiu L, Lai R, Lin Q, Lau E, Thomazy DM, Calame D, et al. Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells. Blood. 2006 Oct 1;108(7):2407-15. Epub 2006 Jun 8. PubMed PMID: 16763206. (Free PMC Article available, 7 images available)
  3. McNamara PS, Smyth RL. Interleukin-9 as a possible therapeutic target in both asthma and chronic obstructive airways disease. Drug News Perspect. 2005 Dec;18(10):615-21. PubMed PMID: 16491163.
  4. Devos S, Cormont F, Vrtala S, Hooghe-Peters E, Pirson F, Snick J. Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. Clin Exp Allergy. 2006 Feb;36(2):174-82. PubMed PMID: 16433854.
  5. Nagato T, Kobayashi H, Kishibe K, Takahara M, Ogino T, Ishii H, et al. Expression of interleukin-9 in nasal natural killer/T-cell lymphoma cell lines and patients. Clin Cancer Res. 2005 Dec 1;11(23):8250-7. PubMed PMID: 16322282.
  6. Poulin LF, Habran C, Stordeur P, Goldman M, McKenzie A, Van Snick J, et al. Interleukin-9 stimulates the production of interleukin-5 in CD4+ T cells. Eur Cytokine Netw. 2005 Sep;16(3):233-9. PubMed PMID: 16266865.
Storage Lyophilized product is stable at room temperature for one month, should be stored desiccated below -20 °C. Upon reconstitution it should be stored at 2 - 8 °C up to one week and for future use below -20 °C. For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA). Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source E. coli
Description
Description:
Interleukin-9 Mouse Recombinant produced in E.Coli is a single, non-glycosylated single polypeptide chain containing 127 amino acids.
AA Sequence:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Gln-Arg-Cys-Ser.
Biological activity:
The ED50 as determined by the dose-dependant stimulation of human MO7e cells is < 0.5 ng/ml, corresponding to a specific Activity of 2 x 10e6 IU/mg.
Molecular weight:
14166 Dalton.
Format
Purity:
>98% Purified by proprietary chromatographic techniques, sterile filtered, purity > 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
State:
Lyophilized
Purified
Reconstitution:
Sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
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