AR50561PU-S KLK7 / Kallikrein-7 (30-253, His-tag)

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0.1 mg / €300.00
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KLK7 / Kallikrein-7

Product Description for KLK7 / Kallikrein-7

KLK7 / Kallikrein-7.
Presentation: Purified

Properties for KLK7 / Kallikrein-7

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms PRSS6, SCCE, Serine protease 6, Stratum corneum chymotryptic enzyme, hK7
Presentation Purified
Molecular weight 27.1 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P49862
Purity > 90 % by SDS - PAGE
Background KLK7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikreins are biomarkers for cancer. The protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. KLK7 may play a role in cancer invasion and metastasis, and increased expression of this protein is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis.
Concentration 1 mg/ml (determined by Bradford assay)
General Readings Talieri,M.,et al. (2011) Anticancer Res. 31 (9), 3093-3100Ramani,V.C., et al. (2011) Biochim. Biophys. Acta 1813 (8), 1525-1531
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human KLK7 protein, fused to His-tag at N-terminus, was expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGSHMIIDGA PCARGSHPWQ VALLSGNQLH CGGVLVNERW VLTAAHCKMN EYTVHLGSDT LGDRRAQRIK ASKSFRHPGY STQTHVNDLM LVKLNSQARL SSMVKKVRLP SRCEPPGTTC TVSGWGTTTS PDVTFPSDLM CVDVKLISPQ DCTKVYKDLL ENSMLCAGIP DSKKNACNGD SGGPLVCRGT LQGLVSWGTF PCGQPNDPGV YTQVCKFTKW INDTMKKHR
Molecular weight:
(249aa)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 2M UREA, 10% glycerol
Purity:
>90% by SDS - PAGE
State:
Liquid purified protein
Purified
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