AR51611PU-N LAMTOR4 (1-99, His-tag)

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0.1 mg / €730.00
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Quick Overview

LAMTOR4

Product Description for LAMTOR4

LAMTOR4.
Presentation: Purified

Properties for LAMTOR4

Product Category Proteins & Growth Factors
Quantity 0.1 mg
Synonyms C7orf59, Ragulator complex protein LAMTOR4
Presentation Purified
Molecular weight 13.1 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q0VGL1
Purity > 85 % by SDS - PAGE
Background LAMTOR4 is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Concentration 0.25 mg/ml (determined by Bradford assay)
General Readings Bar-Peled L., et al. (2011) Cell. 150:1196-1208Burkard T.R., et al. (2012) BMC Syst. Biol. 5:17-17
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description
Description:
Recombinant human LAMTOR4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELV STACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV
Molecular weight:
(122aa) confirmed by MALDI-TOF
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Purity:
>85% by SDS - PAGE
State:
Liquid purified protein
Purified
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