discontinued

PA1191 Leuprolide

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5 mg / €110.00

Quick Overview

Leuprolide

Product Description for Leuprolide

Leuprolide.
Presentation: Purified

Properties for Leuprolide

Product Category Proteins & Growth Factors
Quantity 5 mg
Presentation Purified
Molecular weight 1 kDa
Source Synthetic
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC,
(b) Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}.
Concentration 1.0 mg/ml
General Readings
  1. Chalmers LJ, Casas L, New MI, Blackett PR. Prolongation of growth by treatment of 11-hydroxylase deficiency with depot-leuprolide, growth hormone, and hydrocortisone. J Pediatr Endocrinol Metab. 2006 Oct;19(10):1251-5. PubMed PMID: 17172087.
  2. Re: Olav Erich Yri, Trine Bjoro and Sophie D. Fossa. Failure to achieve castration levels in patients using leuprolide acetate in locally advanced prostate cancer. Eur urol 2006;49:54-8. Eur Urol 2007 Apr;51(4):1146
  3. Mericq G MV, Youlton R R, Willshaw Z ME. [Effectiveness of Leuprolide acetate therapy every three months in central precocious puberty]. Rev Med Chil. 2006 Jul;134(7):821-6. Epub 2006 Aug 29. PubMed PMID: 17130963.
  4. Gustofson RL, Segars JH, Larsen FW. Ganirelix acetate causes a rapid reduction in estradiol levels without adversely affecting oocyte maturation in women pretreated with leuprolide acetate who are at risk of ovarian hyperstimulation syndrome. Hum Reprod. 2006 Nov;21(11):2830-7. Epub 2006 Sep 11. PubMed PMID: 16966348.
  5. Stability of poly(D,L-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems. J Control Release 2006 Oct 10;115(2):158-67
  6. Singh S, Singh J. Phase-sensitive polymer-based controlled delivery systems of leuprolide acetate: in vitro release, biocompatibility, and in vivo absorption in rabbits. Int J Pharm. 2007 Jan 2;328(1):42-8. Epub 2006 Aug 1. PubMed PMID: 16959451.
Storage Lyophilized Leoprolide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Leoprolide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Description
Description:
Synthetic Human Leuprolide is a single, non-glycosylated, polypeptide chain containing 9 amino acids and having a molecular mass of.The b chain has an N-glycosilation site and its structure and glycosilation pattern are very similar to that of pituitary LHRH.
AA Sequence:
Glu-His-Trp-Ser-Tyr-DLeu-Leu-Arg-Pro-NHEt.
Molecular weight:
1209 Dalton
Format
Buffer System:
Lyophilized from a concentrated solution in water containing no additives.
Purity:
>98% Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC,
(b) Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}.
State:
Sterile Filtered White lyophilized (freeze-dried) powder.
Purified
Reconstitution:
It is recommended to reconstitute the lyophilized Leoprolide in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
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