PA023X LIX (CXCL6) (92a.a)

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Product Description for LIX (CXCL6)

Presentation: Purified

Properties for LIX (CXCL6)

Product Category Proteins & Growth Factors
Quantity 20 µg
Synonyms C-X-C motif chemokine 6, CKA-3, Chemokine alpha 3, Granulocyte chemotactic protein 2, SCYB6, Small-inducible cytokine B6
Presentation Purified
Molecular weight 9.8 kDa
Source E. coli
Species (Protein) Mouse
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98 % pure by SDS-PAGE and HPLC analyses
Add. information Centrifuge the vial prior to opening!
Background LIX is a CXC chemokine that signals through the CXCR2 receptor.  It is expressed in monocytes, platelets, endothelial cells, and mast cells.  LIX is a chemoattractant for neutrophils.  The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively.  LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. 
General Readings
  1. Yu JJ, Ruddy MJ, Wong GC, Sfintescu C, Baker PJ, Smith JB, et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood. 2007 May 1;109(9):3794-802. Epub 2007 Jan 3. PubMed PMID: 17202320. (Free PMC Article available, 6 images available)
  2. Van den Steen PE, Van Aelst I, Hvidberg V, Piccard H, Fiten P, Jacobsen C, et al. The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors. J Biol Chem. 2006 Jul 7;281(27):18626-37. Epub 2006 May 3. PubMed PMID: 16672230.
  3. Ueda Y, Kondo M, Kelsoe G. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J Exp Med. 2005 Jun 6;201(11):1771-80. PubMed PMID: 15939792. (Free PMC Article available, 6 images available)
  4. Chandrasekar B, Melby PC, Sarau HM, Raveendran M, Perla RP, Marelli-Berg FM, et al. Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem. 2003 Feb 14;278(7):4675-86. Epub 2002 Dec 4. PubMed PMID: 12468547.
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Recombinant Murine LIX is a 9.8 kDa protein containing 92 amino acid residues.
AA Sequence:
Biological activity:
Assay 1: Determined by its ability to chemoattract Human neutrophils using a concentration range of 10.0-100.0 ng/ml. 
Assay 2: Determined by its ability to chemoattract Murine lymphocytes using a concentration range of 10.0-100.0 ng/ml.
Buffer System:
5 mM Acetic Acid
Endotoxin level:
< 0.1 ng per µg (1EU/µg)
>98% pure by SDS-PAGE and HPLC analyses
Lyophilized (0.2µ Sterile filtered) purified protein
Restore in water to a concentration of 0.1-1.0 mg/ml.
This solution can be stored at 2-8°C for up to 1 week.  For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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