Product Description for mIgG
Properties for mIgG
|Product Category||Proteins & Growth Factors|
|Synonyms||Immunoglobulin G, Immunoglobulin heavy chain constant region gamma 2a|
|Molecular weight||26.6 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 90 % by SDS - PAGE|
|Background||Immunoglobulin G (IgG) are antibody molecules. Each IgG is composed of four peptide chains (two heavy chains gamma and two light chains). Each IgG has two antigen binding sites. IgG antibodies are involved in predominantly the secondary immune response. The presence of specific IgG, in general, corresponds to maturation of the antibody response. It plays an important role in Antibody-dependent cell-mediated cytotoxicity (ADCC) and Intracellular antibody-mediated proteolysis, in which it binds to TRIM21 (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|General Readings||Mallery DL., et al. (2010) Proc Natl Acad Sci. 16(46):19958-90.Bruggemann M., et al. (1989) J Immunol. 1(9):3145-50.|
|Storage||Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.