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Product Description for MOG

Presentation: Purified

Properties for MOG

Product Category Proteins & Growth Factors
Quantity 20 mg
Presentation Purified
Molecular weight 2582 Da
Source Synthetic
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Purity > 98.0% as determined by both RP-HPLC and SDS-PAGE analysis

MOG is a transmembrane protein expressed on the surface of oligodendrocyte cell and on the outermost surface of myelin sheaths. MOG comprises about 0.1% of total CNS myelin protein. The MOG gene is a member of the immunoglobulin gene superfamily and is found within the MHC. The MOG gene is found on chromosome 6p21.3-p22.
Myelin Oligodendrocyte Glycoprotein is a glycoprotein thought to be significant in the process of myelinization of nerves in the central nervous system (CNS).
MOG peptide (35-55) is highly encephalitogenic and can induce strong T and B cell responses.
A single injection of this peptide produces a relapsing- remitting neurologic disease with extensive plaque-like demyelination.
Because of the clinical, histophathologic, and immunologic similarities with multiple sclerosis (MS), the MOG induced demyelinating encephalomyelitis may serve as a model for investigating MS.

Storage Prior to reconstitution store at 2-8°C. 
Following reconstitution store undiluted at 2-8°C for one week or (in aliquots) at -20°C for longer. 
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). 
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Source Synthetic
Myelin Oligodendrocyte Glycoprotein is a single, non-glycosylated polypeptide chain containing 21 amino acids. 
Amino Acid Composition: H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH.
> 98.0% as determined by both RP-HPLC and SDS-PAGE analysis
Sterile Filtered White lyophilized (freeze-dried) powder with no additives
Restore in sterile 18MΩ-cm-1 H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions
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