Product Description for MYD88
MYD88.
Presentation: Purified
Presentation: Purified
Properties for MYD88
| Product Category | Proteins & Growth Factors |
|---|---|
| Target Category | |
| Quantity | 0.5 mg |
| Synonyms | Myeloid differentiation primary response protein MyD88 |
| Presentation | Purified |
| Molecular weight | 38.7 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | Myeloid differentiation primary response gene 88, also known as MYD88, acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This protein increases IL-8 transcription. It is involved in IL-18-mediated signaling pathway. MYD88 activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| General Readings | Kawai T., et al. (2004) Nat. Immunol A. 5:1061-1068Semaan N., et al. (2008) J. Immunol. 180:3485-3491 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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