AR20004PU-N Oncostatin-M

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10 µg / €230.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Oncostatin-M

AR20004PU-N

Product Description for Oncostatin-M

Oncostatin-M.

Properties for Oncostatin-M

Product Category Proteins & Growth Factors
Quantity 10 µg
Synonyms OSM, Oncostatin M, Oncostatin-M
Molecular weight 24.4 kDa
Source E. coli
Species (Protein) Rat
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q65Z15
Purity > 98 % pure by SDS-PAGE and HPLC analyses.
Add. information Centrifuge the vial prior to opening!
Background Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells.
Storage Store the lyophilized protein at -20°C.
Reconstituted Oncostatin-M should be stored in working aliquots at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant Rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues
AA Sequence:
MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI
KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR
Biological activity:
Determined by its ability to stimulate the proliferation of Rat C6 cells. The expected ED50 is 3.0-5.0 µg/ml.
Molecular weight:
(215 aa)
Format
Endotoxin level:
< 0.1 ng/µg of Oncostatin M (< 1EU/µg).
Purity:
>98% pure by SDS-PAGE and HPLC analyses.
State:
Lyophilized (0.2 µm Sterile filtered) purified protein with no additives.
Reconstitution:
Restore in water to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use.
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