Product Description for Oncostatin-M
Properties for Oncostatin-M
|Product Category||Proteins & Growth Factors|
|Synonyms||OSM, Oncostatin M, Oncostatin-M|
|Molecular weight||24.4 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 98 % pure by SDS-PAGE and HPLC analyses.|
|Add. information||Centrifuge the vial prior to opening!|
|Background||Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells.|
|Storage||Store the lyophilized protein at -20°C.
Reconstituted Oncostatin-M should be stored in working aliquots at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.