AR09065PU-N PAK4 (1-591, His-tag)

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0.1 mg / €370.00
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Quick Overview

PAK4

Product Description for PAK4

PAK4.
Presentation: Purified

Properties for PAK4

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms KIAA1142, PAK 4, PAK-4, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4
Presentation Purified
Molecular weight 68.3 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O96013
Purity > 90 %
Application SDS-PAGE
Concentration 1 mg/ml (determined by Bradford assay)
General Readings
  1. Liu Y, Xiao H, Tian Y, Nekrasova T, Hao X, Lee HJ, et al. The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice. Mol Cancer Res. 2008 Jul;6(7):1215-24. doi: 10.1158/1541-7786.MCR-08-0087. PubMed PMID: 18644984. (Free PMC Article available, 6 images available)
  2. Li X, Minden A. PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor. J Biol Chem. 2005 Dec 16;280(50):41192-200. Epub 2005 Oct 14. PubMed PMID: 16227624.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
PAK4 is a member of the group B family of p21-activated kinases (PAK). It's identified as an effector protein for cell division cycle 42(Cdc42) and protein that play an important role in regulating cytoskeletal organization and cell morphology. Its expression is elevated in many cancer cell lines, and suggested that it plays an important role in tumorigenesis. Recombinant PAK4 protein was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFG KRKKRVEISA PSNFEHRVHT GFDQHEQKFT GLPRQWQSLI EESARRPKPL VDPACITSIQ PGAPKTIVRG SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEEPAT TARGGPGKAG SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAIPQSS SSSSRPPTRA RGAPSPGVLG PHASEPQLAP PACTPAAPAV PGPPGPRSPQ REPQRVSHEQ FRAALQLVVD PGDPRSYLDN FIKIGEGSTG IVCIATVRSS GKLVAVKKMD LRKQQRRELL FNEVVIMRDY QHENVVEMYN SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIAAVCLA VLQALSVLHA QGVIHRDIKS DSILLTHDGR VKLSDFGFCA QVSKEVPRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI MVIEMVDGEP PYFNEPPLKA MKMIRDNLPP RLKNLHKVSP SLKGFLDRLL VRDPAQRATA AELLKHPFLA KAGPPASIVP LMRQNRTR
Molecular weight:
68.3 kDa (628 aa)
Format
Buffer System:
50mM Tris-HCl pH 8.0, 2 mM DTT, 10% glycerol
Endotoxin level:
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity:
>90%
State:
Liquid purified protein
Purified
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