Product Description for PPM1D
Properties for PPM1D
|Product Category||Proteins & Growth Factors|
|Synonyms||PP2C-DELTA, Protein phosphatase 1D magnesium-dependent, WIP1, delta isoform|
|Molecular weight||33.2 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 90 % by SDS - PAGE|
|Background||PPM1D also known as Protein phosphatase 1D magnesium-dependent, delta isoform. This protein is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|General Readings||Fiscella M., et al. (1997) Proc Natl Acad Sci u S A, 94 (12): 6048–53.|
|Storage||Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.