AR51812PU-S PPM1D (98-375, His-tag)

Search for all "PPM1D"

50 µg / €300.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

PPM1D

Product Description for PPM1D

PPM1D.
Presentation: Purified

Properties for PPM1D

Product Category Proteins & Growth Factors
Quantity 50 µg
Synonyms PP2C-DELTA, Protein phosphatase 1D magnesium-dependent, WIP1, delta isoform
Presentation Purified
Molecular weight 33.2 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8NEA7
Purity > 90 % by SDS - PAGE
Background PPM1D also known as Protein phosphatase 1D magnesium-dependent, delta isoform. This protein is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase (MAPK/p38) through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis.
Concentration 0.5 mg/ml (determined by Bradford assay)
General Readings Fiscella M., et al. (1997) Proc Natl Acad Sci u S A, 94 (12): 6048–53.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human PPM1D, fused to His-tag at N-terminus, was expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MVAFFAVCDG HGGREAAQFA REHFWGFIKK QKGFTSSEPA KVCAAIRKGF LACHLAMWKK LAEWPKTMTG LPSTSGTTAS VVIIRGMKMY VAHVGDSGVV LGIQDDPKDD FVRAVEVTQD HKPELPKERE RIEGLGGSVM NKSGVNRVVW KRPRLTHNGP VRRSTVIDQI PFLAVARALG DLWSYDFFSG EFVVSPEPDT SVHTLDPQKH KYIILGSDGL WNMIPPQDAI SMCQDQEEKK YLMGEHGQSC AKMLVNRALG RWRQRMLRAD NTSAIVICI
Molecular weight:
(299aa)
Format
Buffer System:
Liquid, In 20mM Tris-HCl (pH8.0) containing 10% glycerol.
Purity:
>90% by SDS - PAGE
State:
Liquid purified protein
Purified
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