Product Description for Prorenin
Properties for Prorenin
|Product Category||Proteins & Growth Factors|
|Synonyms||Angiotensinogenase, HNFJ2, REN, angiotensin-forming enzyme|
|Molecular weight||41,711 Da|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 95 % by SDS-PAGE (Chelated Metal Affinity Chromatography).|
|Add. information||Centrifuge before opening to ensure complete recovery of vial contents.|
|Application||Recombinant Mouse Prorenin.
Contains 8X-Histidine tag at C terminus.
Fully activatable to Renin by catalytic amounts of Trypsin.
381 amino acids + 8 histidine residues.
|Background||Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.|
|Concentration||1.7 mg/ml (OD280nm, E0.1% = 1.10)|
|Storage||Store the antigen at -70°C
Aliquot to avoid multiple freeze/thaw cycles.
Shelf life: one year from despatch.