discontinued

AR31014PU-N Prorenin

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1 mg / €5,100.00

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Prorenin

AR31014PU-N

Product Description for Prorenin

Prorenin.
Presentation: Purified

Properties for Prorenin

Product Category Proteins & Growth Factors
Quantity 1 mg
Synonyms Angiotensinogenase, HNFJ2, REN, angiotensin-forming enzyme
Presentation Purified
Molecular weight 41,711 Da
Source Kidney cells
Species (Protein) Mouse
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P06281
Purity > 95 % by SDS-PAGE (Chelated Metal Affinity Chromatography).
Add. information Centrifuge before opening to ensure complete recovery of vial contents.
Application Recombinant Mouse Prorenin.
Contains 8X-Histidine tag at C terminus.
Fully activatable to Renin by catalytic amounts of Trypsin.
381 amino acids + 8 histidine residues.
Background Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Concentration 1.7 mg/ml (OD280nm, E0.1% = 1.10)
General Readings
  1. A.H. Jan Danser, Jaap Deinum (2005), “Renin, Prorenin and the Putative (Pro)renin Receptor.” Hypertension 46:1069.
  2. Luetscher JA, Kraemer FB, Wilson DM, Schwartz HC, Bryer-Ash M. Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications. N Engl J Med. 1985 May 30;312(22):1412-7. PubMed PMID: 3887168.
Storage Store the antigen at -70°C
Aliquot to avoid multiple freeze/thaw cycles.
Shelf life: one year from despatch.
Source (Human embryonic)
Description
Description:
Recombinant Mouse Prorenin.Contains 8X-Histidine tag at C terminus. Resistant to activation to Renin by Trypsin digestion.380 amino acids + 8 histidine residues.
Molecular weight:
(less glycosylation)
Format
Buffer System:
50mM Tris, pH 8.0 without preservatives.
Purity:
>95% by SDS-PAGE (Chelated Metal Affinity Chromatography).
State:
Liquid purified protein.
Purified
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