AR50113PU-S PSME2 / REG-beta (1-239, His-tag)

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50 µg / €370.00
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PSME2 / REG-beta

Product Description for PSME2 / REG-beta

PSME2 / REG-beta.
Presentation: Purified

Properties for PSME2 / REG-beta

Product Category Proteins & Growth Factors
Target Category
Quantity 50 µg
Synonyms 11S regulator complex subunit beta, Activator of multicatalytic protease subunit 2, PA28b, PA28beta, Proteasome activator, Proteasome activator 28 subunit beta, Proteasome activator complex subunit 2
Presentation Purified
Molecular weight 29.5 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9UL46
Purity > 95 % by SDS - PAGE
Background PSME2, also known as proteasome (prosome, macropain) activator subunit 2, is an IFN-gamma inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens. Downregulation of PSME2 results in abnormal proteasome activation and has been implicated in the development of intimal hyperplasia (IH) in animal models.
Concentration 1.0 mg/ml (determined by Bradford assay)
General Readings Kohda K. et al. (1998) J. Immunol. 160: 4923-4935.Fabunmi R.P. et al. (2001) J. Cell. Sci. 114: 29-36
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human PSME2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
Molecular weight:
(259aa), confirmed by MALDI-TOF
Format
Buffer System:
20 mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT, 0.1mM PMSF
Purity:
>95% by SDS - PAGE
State:
Liquid purified protein
Purified
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