AR09770PU-N PTRH2 / BIT1 (64-179, His-tag)

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0.1 mg / €400.00
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PTRH2 / BIT1

AR09770PU-N

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  • AR09770PU-N

Product Description for PTRH2 / BIT1

PTRH2 / BIT1.
Presentation: Purified

Properties for PTRH2 / BIT1

Product Category Proteins & Growth Factors
Target Category
Quantity 0.1 mg
Synonyms CGI-147, PTH2, Peptidyl-tRNA hydrolase 2 mitochondrial
Presentation Purified
Molecular weight 14.9 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9Y3E5
Purity > 95 %
Background PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1, is a mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondria to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. The natural substrate for PTRH2 may be petidyl-tRNAs which drop off the ribosome during protein synthesis.
Concentration 1.0 mg/ml (determined by Bradford assay)
General Readings Jan Y., et al. (2004) Cell. 116(5):751-62.
De Pereda JM., et al. (2004) J Biol Chem. 279(9):8111-5.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human PTRH2 protein was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MEYKMILVVR NDLKMGKGKV AAQCSHAAVS AYKQIQRRNP EMLKQWEYCG QPKVVVKAPD EETLIALLAH AKMLGLTVSL IQDAGRTQIA PGSQTVLGIG PGPADLIDKV TGHLKLY
Molecular weight:
(137aa), confirmed by MALDI-TOF
Format
Buffer System:
20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Purity:
>95%
State:
Liquid purified protein
Purified
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