discontinued

GTX25323 Rb peptide-phospho S249 + T252 (phospho and non-phospho pair)

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1 packs / €370.00

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Rb peptide-phospho S249 + T252 (phospho and non-phospho pair)

GTX25323

Product Description for Rb peptide-phospho S249 + T252 (phospho and non-phospho pair)

Rb peptide-phospho S249 + T252 (phospho and non-phospho pair).

Properties for Rb peptide-phospho S249 + T252 (phospho and non-phospho pair)

Product Category Proteins & Growth Factors
Quantity 1 packs
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Background Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F 1, PU 1, ATF 2, UBF, Elf 1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Format
Buffer System:
Lyophilized powder with trifluoroacetate salt.
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