Product Description for RBM17 / SPF45
RBM17 / SPF45.
Presentation: Purified
Presentation: Purified
Properties for RBM17 / SPF45
| Product Category | Proteins & Growth Factors |
|---|---|
| Target Category | |
| Quantity | 50 µg |
| Synonyms | 45 kDa-splicing factor, RNA-binding motif protein 17, Splicing factor 45 |
| Presentation | Purified |
| Molecular weight | 47.1 kDa |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | OriGene Technologies GmbH |
| Material safety datasheet | MSDS for Proteins (de) |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % by SDS - PAGE |
| Background | RNA binding motif protein 17, also known as RBM17, is splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. This protein is involved in the regulation of alternative splicing and the utilization of cryptic splice sites. This protein promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| General Readings | Lallena M.J., et al. (2002) Cell. 109:285-296 Carrascal M., et al. (2008) J. Proteome Res. 7:5167-5176 |
| Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
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