AR51979PU-N Renin-1 (22-402, His-tag)

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0.1 mg / €940.00
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Renin-1

Product Description for Renin-1

Renin-1.
Presentation: Purified

Properties for Renin-1

Product Category Proteins & Growth Factors
Quantity 0.1 mg
Synonyms Angiotensinogenase, Kidney renin, Ren, Ren-A, Ren1, Ren1c, Ren1d, Rn-1, Rnr
Presentation Purified
Molecular weight 42.5 kDa
Source Insect cells
Species (Protein) Mouse
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P06281
Purity > 95 % by SDS - PAGE
Background REN1, also known as Renin-1, is a member of the peptidase A1 family. It is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. Androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mR available for translation. This protein is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Also, REN1 was found to be co localized with the lysosomal marker, beta-glucuronidase, by double-fluorescent labeling. Recombint mouse REN1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventiol chromatography techniques.
Concentration 0.25 mg/ml (determined by absorbance at 280nm)
General Readings Ramkumar N., et al. (2013) Am. J. Hypertens. 26(8):965-972.Bandulik S., et al. (2013) Endocrinology 154(8):2712-2722.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
AA Sequence:
LPTRTATFER IPLKKMPSVR EILEERGVDM TRLSAEWGVF TKRPSLTNLT SPVVLTNYLN TQYYGEIGIG TPPQTFKVIF DTGSANLWVP STKCSRLYLA CGIHSLYESS DSSSYMENGS DFTIHYGSGR VKGFLSQDSV TVGGITVTQT FGEVTELPLI PFMLAKFDGV LGMGFPAQAV GGVTPVFDHI LSQGVLKEEV FSVYYNRGSH LLGGEVVLGG SDPQHYQGNF HYVSISKTDS WQITMKGVSV GSSTLLCEEG CAVVVDTGSS FISAPTSSLK LIMQALGAKE KRIEEYVVNC SQVPTLPDIS FDLGGRAYTL SSTDYVLQYP NRRDKLCTLA LHAMDIPPPT GPVWVLGATF IRKFYTEFDR HNNRIGFALA RHHHHHH
Molecular weight:
(387aa)
Format
Buffer System:
Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Endotoxin level:
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity:
>95% by SDS - PAGE
State:
Liquid purified protein
Purified
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