Product Description for Renin-1
Properties for Renin-1
|Product Category||Proteins & Growth Factors|
|Synonyms||Angiotensinogenase, Kidney renin, Ren, Ren-A, Ren1, Ren1c, Ren1d, Rn-1, Rnr|
|Molecular weight||42.5 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 95 % by SDS - PAGE|
|Background||REN1, also known as Renin-1, is a member of the peptidase A1 family. It is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. Androgen and thyroid hormones influence levels of Renin-1 in mouse submandibular gland (SMG) primarily by regulating the amount of Renin-1 mR available for translation. This protein is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Also, REN1 was found to be co localized with the lysosomal marker, beta-glucuronidase, by double-fluorescent labeling. Recombint mouse REN1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventiol chromatography techniques.|
|Concentration||0.25 mg/ml (determined by absorbance at 280nm)|
|General Readings||Ramkumar N., et al. (2013) Am. J. Hypertens. 26(8):965-972.Bandulik S., et al. (2013) Endocrinology 154(8):2712-2722.|
|Storage||Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.