Product Description for Sentan / SNTN
Properties for Sentan / SNTN
|Product Category||Proteins & Growth Factors|
|Synonyms||S100 calcium-binding protein A1-like, S100-A1-like, S100A1L|
|Molecular weight||18.6 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 90 %|
|Background||SNTN, also known as Sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|General Readings||Muzny D.M., et al. (2006) Nature. 440:1194-1198.
Kubo A., et al. (2008) Mol. Biol. Cell 19:5338-5346.
|Storage||Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.