AR09983PU-L Sentan / SNTN (1-147, His-tag)

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0.5 mg / €750.00
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Sentan / SNTN

AR09983PU-L

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  • AR09983PU-L

Product Description for Sentan / SNTN

Sentan / SNTN.
Presentation: Purified

Properties for Sentan / SNTN

Product Category Proteins & Growth Factors
Quantity 0.5 mg
Synonyms S100 calcium-binding protein A1-like, S100-A1-like, S100A1L
Presentation Purified
Molecular weight 18.6 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
A6NMZ2
Purity > 90 %
Background SNTN, also known as Sentan, belongs to the S-100 family. SNTN is shown to localize exclusively to the bridging structure between the cell membrane and peripheral singlet microtubules, which specifically exists in the narrowed distal portion of cilia. Exogenously expressed sentan showed affinity for the membrane protrusions, and a protein-lipid binding assay revealed that sentan bound to phosphatidylserine. These findings suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport.
Concentration 0.5 mg/ml (determined by Bradford assay)
General Readings Muzny D.M., et al. (2006) Nature. 440:1194-1198.
Kubo A., et al. (2008) Mol. Biol. Cell 19:5338-5346.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human SNTN protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGGCMHSTQD KSLHLEGDPN PSAAPTSTCA PRKMPKRISI SKQLASVKAL RKCSDLEKAI ATTALIFRNS SDSDGKLEKA IAKDLLQTQF RNFAEGQETK PKYREILSEL DEHTENKLDF EDFMILLLSI TVMSDLLQNI RNVKIMK
Molecular weight:
(167aa), confirmed by MALDI-TOF
Format
Buffer System:
20mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.15M NaCl, 1mM DTT
Purity:
>90%
State:
Liquid purified protein
Purified
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