AR51619PU-N SMARCA4 (362-549, His-tag)

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0.5 mg / €730.00
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Quick Overview

SMARCA4

Product Description for SMARCA4

SMARCA4.
Presentation: Purified

Properties for SMARCA4

Product Category Proteins & Growth Factors
Quantity 0.5 mg
Synonyms BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, Transcription activator BRG1 isoform A, hSNF2b
Presentation Purified
Molecular weight 25.0 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9HBD4
Purity > 80 % by SDS - PAGE
Background SMARCA4 is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene..
Concentration 1.0 mg/ml (determined by Bradford assay)
General Readings Dykhuizen,E.C, et al. (2013) Nature 497 (7451), 624-627 Bai,J., et al. (2013) PLoS ONE 8 (3), E59772
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description
Description:
Recombinant human SMARCA4 protein, fused to His-tag at N-terminus, was expressed in E.coli.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGSDPVEILQ EREYRLQARI AHRIQELENL PGSLAGDLRT KATIELKALR LLNFQRQLRQ EVVVCMRRDT ALETALNAKA YKRSKRQSLR EARITEKLEK QQKIEQERKR RQKHQEYLNS ILQHAKDFKE YHRSVTGKIQ KLTKAVATYH ANTEREQKKE NERIEKERMR RLMAEDEEGY RKLIDQKKDK R
Molecular weight:
(211aa)
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Purity:
>80% by SDS - PAGE
State:
Liquid purified protein
Purified
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