discontinued

GTX25257 Src peptide-phospho Y529 (phospho and non-phospho pair)

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1 packs / €370.00

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Src peptide-phospho Y529 (phospho and non-phospho pair)

GTX25257

Product Description for Src peptide-phospho Y529 (phospho and non-phospho pair)

Src peptide-phospho Y529 (phospho and non-phospho pair).

Properties for Src peptide-phospho Y529 (phospho and non-phospho pair)

Product Category Proteins & Growth Factors
Quantity 1 packs
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Background Src (also known as pp60src) is a non-receptor tyrosine kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. Tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of the catalytic domain residue (tyrosine 418 in the human sequence), thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylatedleading to full activation.
Format
Buffer System:
Lyophilized powder with trifluoroacetate salt.
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