AR51453PU-S SVIP (1-77, His-tag)

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50 µg / €370.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

SVIP

Product Description for SVIP

SVIP.
Presentation: Purified

Properties for SVIP

Product Category Proteins & Growth Factors
Quantity 50 µg
Synonyms DKFZp313A2432, Small VCP/p97 interacting protein, Small VCP/p97-interacting protein
Presentation Purified
Molecular weight 10.8 kDa
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8NHG7
Purity > 85 % by SDS - PAGE
Background Small VCP/p97-interacting protein, also known as SVIP, is involved in a variety of cellular processes, including membrane fusion and ubiquitin-dependent protein degradation. SVIP functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Overexpression of SVIP, on the other hand, increased the levels of p62 protein and enhanced starvation-activated autophagy as well as promoted sequestration of polyubiquitinated proteins and p62 in autophagosomes.
Concentration 0.25 mg/ml (determined by Bradford assay)
General Readings Wang Y., et al. (2011) PLoS One. 6(8): e24478.Ballar P., et al. (2007) J Bio Chem 23(47): 33908-14.
Storage Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description
Description:
Recombinant human SVIP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MGSSHHHHHH SSGLVPRGSH MGSMGLCFPC PGESAPPTPD LEEKRAKLAE AAERRQKEAA SRGILDVQSV QEKRKKKEKI EKQIATSGPP PEGGLRWTVS
Molecular weight:
(100aa) confirmed by MALDI-TOF
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 2mM DTT
Purity:
>85% by SDS - PAGE
State:
Liquid purified protein
Purified
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