Antibodies to Cyclin Family - Product Review 16

Introduction

Oscillations in the activity of the Cdk family of protein kinases drive the eukaryotic cell cycle. These enzymes consist of a catalytic (Cdk) and a regulatory subunit (Cyclin).

Their activity is regulated by phosphorylation of Cdks, binding of stoichiometric kinase inhibitors and regulated proteolysis of the cyclins.The Cdk/cyclin family contains five Cdks (Cdk1, 2, 3, 4 and 6) and four cyclin classes (cyclin A, B, D and E, see table below.) that regulate the cell cycle; three Cdks (Cdk7, 8 and 9) and three cyclin classes (cyclin C, H and T) that regulate transcription. Activating the cell-cycle Cdks requires phosphorylation of a conserved threonine as well as binding of cyclin.

Antibody Tools for Detection of Cyclin Proteins

Acris Antibodies offers a broad panel of monoclonal and polyclonal antibodies for the immunological detection of members of the Cyclin protein family.

Picture Gallery

Staining of human tonsil using DM175 clone 6E6 antibody to Cyclin A1. Note nuclear staining of proliferating cells.

Staining of human tonsil using DM175 clone 6E6 antibody to Cyclin A1. Note nuclear staining of proliferating cells.

Staining of human tonsil for Cyclin D3 using SM1481

Staining of human tonsil for Cyclin D3 using SM1481

Staining of human placenta for Cyclin E1 using DM181

Staining of human placenta for Cyclin E1 using DM181

Available Antibodies to the Cyclin Family

Anti- Cyclin A (CCNA), Cyclin A1 (CCNA1), Cyclin B1 (CCNB), Cyclin B2 (CCNB2), Cyclin B3 (CCNB3), Cyclin C (CCNC), Cyclin D1 (CCND1), Cyclin D2 (CCND2), Cyclin D3 (CCND3), Cyclin E (CCNE), Cyclin E1 (CCNE1), Cyclin E2 (CCNE2), Cyclin G (CCNG), Cyclin G1 (CCNG1), Cyclin G2 (CCNG2), Cyclin H (CCNH), Cyclin I (CCNI), Cyclin J (CCNJ), Cyclin K (CCNK), Cyclin L1 (CCNL1), Cyclin L2 (CCNL2), Cyclin T1 (CCNT1), Cyclin T2 (CCNT2) antibody

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cyclin A1 antibody

Immunohistochemical analysis in paraffin-embedded human breast carcinoma tissue using Cyclin A1 antibody (Cat.-No. AP06080PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cyclin A1 antibody

ELISA: Cyclin A1 Antibody [28970002] Rabbit Hu E, P
50 µg / €440.00
  Novus Biologicals Inc.

Cyclin A1 antibody

Immunohistochemistry: Cyclin A1 Antibody [NB100-91727] -  Cyclin A1 antibody (R436) [NB100-91727] - in paraffin-embedded human breast carcinoma tissue. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Cyclin A1 antibody

Cyclin A1 Rabbit Hu E, ICC/IF, IP, P, WB
50 µl / €480.00
  Novus Biologicals Inc.

Cyclin A2 antibody

Immunohistochemical analysis in paraffin-embedded human lung carcinoma tissue using Cyclin A2 antibody (Cat.-No. AP06079PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cyclin A2 (N-term) antibody

Western blot analysis of anti-CCNA2(N-term) Pab in HL60 cell line lysates (35ug/lane). CCNA2(arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cyclin A2 (C-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CCNA2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cyclin A2 antibody

Immunoprecipitation of CCNA2 transfected lysate using anti-CCNA2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CCNA2 MaxPab mouse polyclonal antibody (B01) (H00000890-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

Cyclin A2 antibody

Human HepG2; WB Suggested Anti-CCNA2 Antibody Titration: 1ug/ml. Positive Control: HepG2 cell lysate. CCNA2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells.; CCNA2 antibody - C-terminal region (AVARP03045_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Cyclin A2 antibody

ELISA: Cyclin A2 Antibody [28980002] Rabbit Hu E
50 µg / €440.00
  Novus Biologicals Inc.

Cyclin A2 antibody

Cyclin A2 Mouse IgG2a E43.2 Purified Hu P, WB
0.1 mg / €320.00
  Novus Biologicals Inc.

Cyclin A2 antibody

Cyclin A2 Mouse IgG1 AT10.2 Purified Hu C, IP, P
0.1 mg / €320.00
  Novus Biologicals Inc.

Cyclin A2 antibody

Immunohistochemistry-Paraffin: Cyclin A2 Antibody (6E6) [NB110-14736] - Formalin fixed paraffin embedded human tonsil stained with Cyclin A antibody. Mouse IgG1 6E6 Hu P, WB
0.5 ml / €420.00
  Novus Biologicals Inc.

Cyclin A2 (C-term) antibody

Immunohistochemistry: Cyclin A2 (C-term) Antibody (Y193) [NB110-56899] - Immunohistochemical analysis of paraffin-embedded skin carcinoma using anti-Cyclin A (C-term) (catalog #110-56899). Rabbit IgG Y193 Aff - Purified Hu ICC/IF, IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cyclin A2 antibody

Immunohistochemistry: Cyclin A2 Antibody [NB600-495] - Anti-Cyclin A antibody was diluted 1:500 to detect Cyclin A in human testes tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. Rabbit IgG Serum Hu, Ms, Rt E, IP, P, WB
0.1 ml / €510.00
  Novus Biologicals Inc.

Cyclin A2 antibody

Immunohistochemistry: Cyclin A2 Antibody [NBP1-31330] - Immunohistochemical analysis of paraffin-embedded NCIN87 Xenograft, using NBP1-31330 at 1:500 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Cyclin B1 antibody

Immunohistochemical analysis of paraffin-embedded
human breast carcinoma tissue using Cyclin B1 Antibody Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Cyclin B1 antibody

Immunohistochemical analysis of paraffin-embedded
human breast carcinoma tissue using Cyclin B1 Antibody Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

Cyclin B1 antibody

Human Jurkat; WB Suggested Anti-CCNB1 Antibody Titration: 0.125ug/ml. ELISA Titer: 1:312500. Positive Control: Jurkat cell lysate. CCNB1 is supported by BioGPS gene expression data to be expressed in Jurkat.; CCNB1 antibody - C-terminal region (ARP30161_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Cyclin B1 antibody

Breast carcinoma stained with Anti-Cyclin B1 antibody. Rabbit Purified Hu, Ms, Rt IP, P, WB
1 ml / €440.00
  Acris Antibodies GmbH

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