GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).



In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
GTX77690

GABRA2 antibody

Western blot analysis of HepG2 cell lysate using GABRA2 antibody (GTX77690)
Rabbit IgG Aff - Purified Hu WB
0.1 mg / €350.00
  GeneTex Inc.
AVARP13026_T100

GABRA2 antibody

Human HepG2; WB Suggested Anti-GABRA2 Antibody Titration: 1.25ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; GABRA2 antibody - middle region (AVARP13026_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology
NB300-149

GABRA2 antibody

Western Blot: GABA A receptor alpha 2 Antibody [NB300-149] - Western blot of 10 ug of rat cortex lysate showing immunolabeling of the ~53k a2-subunit of the GABAA-R. Rabbit Serum Rt WB
50 µl / €350.00
  Novus Biologicals Inc.
NB300-192

GABRA2 antibody

Western Blot: GABA-A receptor alpha 2 subunit Antibody [NB300-192] - Western blot of rat brain lysates from wild type (Control) and a2-knockout (a2-K/O) animals showing specific immunolabeling of the ~51k a2-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a2-knockout animals. Rabbit Aff - Purified Ms, Rt WB
0.1 ml / €360.00
  Novus Biologicals Inc.
AP08653PU-N

GABRA3 (N-term) antibody

Western blot of mouse brain lysates from wild type (Control) and Alpha-3 knockout (Alpha-3 K/O) animals showing specific immunolabeling of the ~51k Alpha-3 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-3 knockout animals. Rabbit IgG Aff - Purified Bov, Can, Hu, Rt, Ze C, WB
0.1 ml / €360.00
  Acris Antibodies GmbH
GTX77691

GABRA3 antibody

Immunohistochemistry of mouse bulbus using GABRA3 antibody (GTX77691)
Rabbit IgG Aff - Purified Hu WB
0.1 mg / €350.00
  GeneTex Inc.
H00002556-M02

GABRA3 antibody

GABRA3 Mouse IgG2a 3C6 Purified Hu E
0.1 mg / €360.00
  Abnova Taiwan Corp.
ARP34981_T100

GABRA3 antibody

mouse bulbus; GABRA3 antibody - middle region (ARP34981_T100) in mouse bulbus cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology
AVARP13027_T100

GABRA3 antibody

mouse bulbus; GABRA3 antibody - N-terminal region (AVARP13027_T100) in mouse bulbus cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt
0.1 mg / €310.00
  AVIVA Systems Biology
NB100-61096

GABRA3 antibody

Western Blot: GABA A Receptor alpha 3 Antibody [NB100-61096] - Rat brain lysates from wild type (Control) and a3-knockout (a3-K/O) animals showing specific immunolabeling of the ~51k a3-subunit of the GABAA-R. The labeling was absent from a lysate prepared from á3-knockout animals. Rabbit IgG Aff - Purified Ms, Rt P, WB
0.1 ml / €360.00
  Novus Biologicals Inc.
12979-1-AP

GABRA4 antibody

Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 12979-1-AP(GABRA4 antibody) at dilution of 1:500 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.15 ml / €285.00
  Proteintech Group, Inc.
AP05915PU-N

GABRA4 (C-term) antibody

GABRA4 Rabbit IgG Purified Bov, Hu, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH
AP08654PU-N

GABRA4 antibody

Figure 1. Western blot of rat Hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k Alpha-4 subunit of the GABAA-R. Rabbit IgG Aff - Purified Rt WB
0.1 ml / €360.00
  Acris Antibodies GmbH
AP08655PU-N

GABRA4 (N-term) antibody

Western blot of 10 µg of Rat brain Hippocampus (Hipp)  lysate showing immunolabeling of the ~64k Alpha-4 subunit of the GABAA-R. Rabbit IgG Aff - Purified Rt C, WB
0.1 ml / €360.00
  Acris Antibodies GmbH
AP16891PU-N

GABRA4 antibody

Antibody (0.1µg/ml) staining of Human Frontal Cortex lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH
PAB9625

GABRA4 antibody

Western blot of 10 µg of rat brain hippocampus (Hipp) lysate showing immunolabeling of the ~64k a4 subunit of the Gabra4. Rabbit Rt WB
0.1 ml / €400.00
  Abnova Taiwan Corp.
PAB9682

GABRA4 antibody

GABRA4 Rabbit Rt WB
0.1 ml / €400.00
  Abnova Taiwan Corp.
PAB11468

GABRA4 antibody

GABRA4 polyclonal antibody ( Cat # PAB11468 ) ( 0.1 µg/ml ) staining of human frontal cortex lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.
NB300-193

GABRA4 antibody

Western Blot: GABA A Receptor alpha 4 Antibody [NB300-193] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k a4-subunit of the GABAA-R. Rabbit Purified Rt WB
0.1 ml / €360.00
  Novus Biologicals Inc.
NB300-193PEP

GABRA4 Control Peptide

Western Blot: GABA A Receptor alpha 4 Peptide [NB300-193PEP] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k a4-subunit of the GABAA-R. Rt
50 µl / €360.00
  Novus Biologicals Inc.

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