GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).



In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



  1. Quick-Filters:
  2. Cited (1)

Items 21 to 40 of 47 total

per page
Page:
  1. 1
  2. 2
  3. 3

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRB2 (C-term) antibody

GABRB2 Rabbit IgG Purified Can, Hu, Mky, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

GABRB2 antibody

Human HepG2; WB Suggested Anti-GABRB2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: HepG2 cell lysate; GABRB2 antibody - N-terminal region (ARP34989_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

GABRB2 antibody

Human Jurkat; WB Suggested Anti-GABRB2 Antibody Titration: 1.25ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; GABRB2 antibody - N-terminal region (ARP35338_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

GABRD (N-term) antibody

GABRD Rabbit IgG Purified Ms, Rt C, IP, WB
0.1 ml / €500.00
  Acris Antibodies GmbH

GABRD antibody

Human Muscle; GABRD antibody - N-terminal region (AVARP13032_P050) in Human Muscle cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

GABRD antibody

Human; WB Suggested Anti-GABRD Antibody. . Titration: 5.0 ug/ml. . Positive Control: Jurkat/HepG2; GABRD antibody - N-terminal region (AVARP13032_T100) in Human cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

GABRE antibody

Human Placenta; WB Suggested Anti-GABRE Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Placenta; GABRE antibody - middle region (ARP35342_P050) in Human Placenta cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

GABRG2 pSer327 antibody

Figure 1. Western blot of rat cortex showing specific immunolabeling of the ~45k GABAA Gamma-2 protein phosphorylated at Ser327 (Control). Immunolabeling is blocked by the phospho-peptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €380.00
  Acris Antibodies GmbH

GABRG2 antibody

GABRG2 Rabbit IgG Serum Chk, Hu, Mky, Ms, Rt, Ze WB
50 µl / €510.00
  Acris Antibodies GmbH

GABRG2 antibody

Human HepG2; WB Suggested Anti-GABRG2 Antibody Titration: 1.25ug/ml. Positive Control: HepG2 cell lysate; GABRG2 antibody - C-terminal region (ARP35574_T100) in Human HepG2 cells using Western Blot Rabbit Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

GABRG3 antibody

GABRG3 Rabbit Aff - Purified Can, Chk, Dros, Hu, Ms, Rt
0.1 mg / €310.00
  AVIVA Systems Biology

GABRP antibody

Human Intestine; GABRP antibody - N-terminal region (AVARP13034_P050) in Human Intestine cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

GABRP antibody

Human; WB Suggested Anti-GABRP Antibody. . Titration: 1.25 ug/ml. . Positive Control: HepG2/Jurkat; GABRP antibody - N-terminal region (AVARP13034_T100) in Human cells using Western Blot Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

GABRQ antibody

Human Jurkat; WB Suggested Anti-GABRQ Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Jurkat cell lysate; GABRQ antibody - N-terminal region (ARP35283_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GABAA Receptor alpha 6

GABAA Receptor alpha 6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GABAA Receptor alpha 6

GABAA Receptor alpha 6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

GABRA1

GABRA1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GABRA1

GABRA1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

GABRA3

GABRA3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GABRA3

GABRA3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Items 21 to 40 of 47 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • LinkedIn