GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).



In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



  1. Quick-Filters:
  2. Cited (1)

Items 21 to 40 of 69 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRA3 antibody

Western Blot: GABA A Receptor alpha 3 Antibody [NB100-61096] - Rat brain lysates from wild type (Control) and a3-knockout (a3-K/O) animals showing specific immunolabeling of the ~51k a3-subunit of the GABAA-R. The labeling was absent from a lysate prepared from á3-knockout animals. Rabbit IgG Aff - Purified Ms, Rt P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

GABRA4 (C-term) antibody

GABRA4 Rabbit IgG Purified Bov, Hu, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

GABRA4 antibody

Western blot of 10 µg of rat brain hippocampus (Hipp) lysate showing immunolabeling of the ~64k a4 subunit of the Gabra4. Rabbit Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

GABRA4 antibody

GABRA4 Rabbit Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

GABRA4 antibody

GABRA4 polyclonal antibody ( Cat # PAB11468 ) ( 0.1 µg/ml ) staining of human frontal cortex lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

GABRA4 antibody

Western Blot: GABA A Receptor alpha 4 Antibody [NB300-193] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k a4-subunit of the GABAA-R. Rabbit Purified Rt WB
0.1 ml / €380.00
  Novus Biologicals Inc.

GABRA4 Control Peptide

Western Blot: GABA A Receptor alpha 4 Peptide [NB300-193PEP] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k a4-subunit of the GABAA-R. Rt
50 µl / €380.00
  Novus Biologicals Inc.

GABRA4 (N-term) antibody

Western blot of 10 µg of rat brain hippocampus (Hipp) lysate showing immunolabeling of the ~64k a4-subunit of the GABAA -R. Rabbit Purified Rt P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

GABRA4 antibody

Immunohistochemistry-Paraffin: GABA A Receptor alpha 4 Antibody [NBP1-18844] - (2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Bov, Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

GABRA5 (C-term) antibody

GABRA5 Rabbit IgG Purified Ms, Rt WB
0.1 ml / €500.00
  Acris Antibodies GmbH

GABRA5 antibody

Western Blot: GABA A receptor alpha 5 subunit Antibody [NB300-195] - Western blot detection of the ~55kDa a5-subunit of GABAa-R from 7ug of rat hippocampal lysate using NB300-195. Rabbit Purified Rt WB
0.1 ml / €380.00
  Novus Biologicals Inc.

GABRB1 antibody

Immunohistochemistry (IHC) analysis of GABA-RB antibody (Cat.-No.: AP06129PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GABRB1 antibody

Figure 1. Western blot analysis of extracts from PC12 cells using GABRB1 antibody AP08059PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Acris Antibodies GmbH

GABRB1 antibody

Figure 1. Western blot analysis of extracts from PC12 cells using GABRB1 antibody AP08059PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €230.00
  Acris Antibodies GmbH

GABRB1 antibody

GABRB1 Rabbit Aff - Purified Bov, Hu, Ms, Rt
0.1 mg / €310.00
  AVIVA Systems Biology

GABRB1 antibody

GABRB1 Rabbit IgG Aff - Purified Hu, Ms, Rt P
0.1 mg / €420.00
  Novus Biologicals Inc.

GABRB1 antibody

Western Blot: GABA A Receptor beta 1 Antibody [NB300-197] - Rat cerebellar (Cb) and hippocampal (Hipp) lysates showing specific immunolabeling of the ~55k ß1-subunit of the GABAA-R. Rabbit Purified Rt Dot, P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

GABRB2 (C-term) antibody

GABRB2 Rabbit IgG Purified Can, Hu, Mky, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

GABRB2 antibody

Human HepG2; WB Suggested Anti-GABRB2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: HepG2 cell lysate; GABRB2 antibody - N-terminal region (ARP34989_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

GABRB2 antibody

Human Jurkat; WB Suggested Anti-GABRB2 Antibody Titration: 1.25ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; GABRB2 antibody - N-terminal region (ARP35338_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

Items 21 to 40 of 69 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  • LinkedIn